MicroRNA-24 Regulates Vascularity After Myocardial Infarction
نویسندگان
چکیده
منابع مشابه
MicroRNA-24 regulates vascularity after myocardial infarction.
BACKGROUND Myocardial infarction leads to cardiac remodeling and development of heart failure. Insufficient myocardial capillary density after myocardial infarction has been identified as a critical event in this process, although the underlying mechanisms of cardiac angiogenesis are mechanistically not well understood. METHODS AND RESULTS Here, we show that the small noncoding RNA microRNA-2...
متن کاملHeart Failure MicroRNA-24 Regulates Vascularity After Myocardial Infarction
Background—Myocardial infarction leads to cardiac remodeling and development of heart failure. Insufficient myocardial capillary density after myocardial infarction has been identified as a critical event in this process, although the underlying mechanisms of cardiac angiogenesis are mechanistically not well understood. Methods and Results—Here, we show that the small noncoding RNA microRNA-24 ...
متن کاملMicroRNA-24 regulates cardiac fibrosis after myocardial infarction
Cardiac fibrosis after myocardial infarction (MI) has been identified as a key factor in the development of heart failure. Although dysregulation of microRNA (miRNA) is involved in various pathophysiological processes in the heart, the role of miRNA in fibrosis regulation after MI is not clear. Previously we observed the correlation between fibrosis and the miR-24 expression in hypertrophic hea...
متن کاملGrowth differentiation factor 5 regulates cardiac repair after myocardial infarction.
OBJECTIVES The aim of this study was to examine the function of the bone morphogenic protein growth differentiation factor 5 (Gdf5) in a mouse model of myocardial infarction (MI). BACKGROUND The Gdf5 has been implicated in skeletal development, but a potential role in the heart had not been studied. METHODS The Gdf5-knockout (KO) and wild-type (WT) mice were subjected to permanent left ante...
متن کاملParkin Regulates Mitochondrial Autophagy After Myocardial Infarction in Rats
BACKGROUND To study the role of Parkin in the regulation of mitochondrial autophagy in the heart by assessing mitochondrial autophagy and changes in Parkin protein expression in rat myocardium after myocardial infarction (MI). MATERIAL AND METHODS Rats were randomly assigned to three groups: control, sham, and MI. Four weeks after induction of MI, ultrasonic examination of the rats was performe...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Circulation
سال: 2011
ISSN: 0009-7322,1524-4539
DOI: 10.1161/circulationaha.111.039008